Target:USP15
Fields:Mitophagy - animal
Gene Name:USP15
Protein Name:Ubiquitin carboxyl-terminal hydrolase 15
Human Gene Id:9958
Human Swiss Prot No:Q9Y4E8
Mouse Gene Id:14479
Mouse Swiss Prot No:Q8R5H1
Rat Swiss Prot No:Q9R085
Immunogen:The antiserum was produced against synthesized peptide derived from human USP15. AA range:81-130
Specificity:USP15 Polyclonal Antibody detects endogenous levels of USP15 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:USP15;KIAA0529;Ubiquitin carboxyl-terminal hydrolase 15;Deubiquitinating enzyme 15;Ubiquitin thioesterase 15;Ubiquitin-specific-processing protease 15;Unph-2;Unph4
Observed Band(KD):115kD
Background: This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011],
Function:catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,tissue specificity:Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.,
Subcellular Location:Cytoplasm . Nucleus . Mitochondrion .
Expression:Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.