Target：UBP14

Gene Name：USP14 TGT

Protein Name：Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)

Human Gene Id：9097

Human Swiss Prot No：P54578

Mouse Swiss Prot No：Q9JMA1

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：UBP14 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：54kD

Background： This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,caution:Was originally (Ref.1) thought to be a queuine tRNA-ribosyltransferase.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 ubiquitin-like domain.,subunit:Homodimer .,

Subcellular Location：Cytoplasm . Cell membrane ; Peripheral membrane protein .

Expression： Placenta,Skin,