Target：WAVE3

Fields：Adherens junction;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Salmonella infection;Choline metabolism in cancer

Gene Name：WASF3

Protein Name：Wiskott-Aldrich syndrome protein family member 3

Human Gene Id：10810

Human Swiss Prot No：Q9UPY6

Mouse Gene Id：245880

Mouse Swiss Prot No：Q8VHI6

Immunogen：The antiserum was produced against synthesized peptide derived from human WASF3. AA range:151-200

Specificity：WAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：WASF3;KIAA0900;SCAR3;WAVE3;Wiskott-Aldrich syndrome protein family member 3;WASP family protein member 3;Protein WAVE-3;Verprolin homology domain-containing protein 3

Observed Band(KD)：55kD

Background： This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],

Function：domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,

Subcellular Location：Cytoplasm, cytoskeleton.

Expression：Expressed in ovary and brain.