Target：WAVE2

Fields：Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Yersinia infection;Choline metabolism in cancer

Gene Name：WASF2

Protein Name：Wiskott-Aldrich syndrome protein family member 2

Human Gene Id：10163

Human Swiss Prot No：Q9Y6W5

Mouse Gene Id：242687

Mouse Swiss Prot No：Q8BH43

Immunogen：The antiserum was produced against synthesized peptide derived from human WASF2. AA range:141-190

Specificity：WAVE2 Polyclonal Antibody detects endogenous levels of WAVE2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：WASF2;WAVE2;Wiskott-Aldrich syndrome protein family member 2;WASP family protein member 2;Protein WAVE-2;Verprolin homology domain-containing protein 2

Observed Band(KD)：55kD

Background： This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],

Function：domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subcellular location:At the interface between the lamellipodial actin meshwork and the membrane.,subunit:Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.,tissue specificity:Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.,

Subcellular Location：Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Basolateral cell membrane . At the interface between the lamellipodial actin meshwork and the membrane. .

Expression：Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.