Target：UBA2
Fields：Ubiquitin mediated proteolysis
Gene Name：UBA2
Protein Name：SUMO-activating enzyme subunit 2
Human Gene Id：10054
Human Swiss Prot No：Q9UBT2
Mouse Swiss Prot No：Q9Z1F9
Immunogen：The antiserum was produced against synthesized peptide derived from human Uba2. AA range:591-640
Specificity：UBA2 Polyclonal Antibody detects endogenous levels of UBA2 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：UBA2;SAE2;UBLE1B;HRIHFB2115;SUMO-activating enzyme subunit 2;Anthracycline-associated resistance ARX;Ubiquitin-like 1-activating enzyme E1B
Observed Band(KD)：71kD
Background： Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],
Function：function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,
Subcellular Location：Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Expression： Brain,Cervix carcinoma,Fetal brain,Placenta,Skin,Testis,
