Target：VMAT2

Fields：Synaptic vesicle cycle;Serotonergic synapse;Dopaminergic synapse;Parkinson disease;Cocaine addiction;Amphetamine addiction;Alcoholism

Gene Name：SLC18A2 SVMT VMAT2

Protein Name：Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)

Human Gene Id：6571

Human Swiss Prot No：Q05940

Mouse Swiss Prot No：Q8BRU6

Rat Swiss Prot No：Q01827

Immunogen：Synthesized peptide derived from human protein . at AA range: 1-80

Specificity：VMAT2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：56kD

Background： The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],

Function：function:Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.,online information:Vesicular monoamine transporter entry,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,

Subcellular Location：Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Expression： Brain,Platelet,Substantia nigra,Testis,