Target：ZCCHV

Gene Name：ZC3HAV1 ZC3HDC2 PRO1677

Protein Name：Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)

Human Gene Id：56829

Human Swiss Prot No：Q7Z2W4

Mouse Swiss Prot No：Q3UPF5

Rat Swiss Prot No：Q8K3Y6

Immunogen：Synthesized peptide derived from human protein . at AA range: 211-260

Specificity：ZCCHV Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：99kD

Background： This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008],

Function：domain:The second and fourth zinc fingers are involved in binding to specific viral RNAs.,function:Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.,subunit:Interacts with EXOSC5.,

Subcellular Location：[Isoform 1]: Cytoplasm . Nucleus . Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. .; [Isoform 2]: Cytoplasm .

Expression： Brain,Endometrium,Epithelium,Fetal liver,Kidney,Ovarian car