Target：TRY2

Fields：Neuroactive ligand-receptor interaction;Pancreatic secretion;Protein digestion and absorption;Influenza A

Gene Name：PRSS2 TRY2 TRYP2

Protein Name：Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)

Human Gene Id：5645

Human Swiss Prot No：P07478

Mouse Swiss Prot No：P07146

Rat Swiss Prot No：P00763

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：TRY2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：27kD

Background： This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],

Function：catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,

Subcellular Location：Secreted, extracellular space.

Expression：Expressed in Paneth cells, at the base of small intestinal crypts.