Target：TRPC1
Fields：Axon guidance;Glutamatergic synapse;Serotonergic synapse;GnRH secretion;Pancreatic secretion
Gene Name：TRPC1 TRP1
Protein Name：Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
Human Gene Id：7220
Human Swiss Prot No：P48995
Mouse Swiss Prot No：Q61056
Rat Swiss Prot No：Q9QX01
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：TRPC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：87kD
Background：transient receptor potential cation channel subfamily C member 1(TRPC1) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function：function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TRPC3. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Seems to be ubiquitous.,
Subcellular Location：Membrane; Multi-pass membrane protein.
Expression：Seems to be ubiquitous.
