Target：Tropomyosin α

Fields：Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;MicroRNAs in cancer;Hypertrophic cardiomyopathy;Dilated cardiomyopathy

Gene Name：TPM1

Protein Name：Tropomyosin alpha-1 chain

Human Gene Id：7168

Human Swiss Prot No：P09493

Mouse Gene Id：22003

Mouse Swiss Prot No：P58771

Rat Gene Id：24851

Rat Swiss Prot No：P04692

Immunogen：The antiserum was produced against synthesized peptide derived from human Tropomyosin alpha. AA range:40-89

Specificity：Tropomyosin α Polyclonal Antibody detects endogenous levels of Tropomyosin α protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TPM1;C15orf13;TMSA;Tropomyosin alpha-1 chain;Alpha-tropomyosin;Tropomyosin-1

Observed Band(KD)：35kD

Background： This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by

Function：alternative products:Additional isoforms seem to exist,disease:Defects in TPM1 are the cause of cardiomyopathy dilated type 1Y (CMD1Y) [MIM:611878]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudde

Subcellular Location：Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .

Expression：Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.