Target:TROP-2
Gene Name:TACSTD2
Protein Name:Tumor-associated calcium signal transducer 2
Human Gene Id:4070
Human Swiss Prot No:P09758
Mouse Gene Id:56753
Mouse Swiss Prot No:Q8BGV3
Rat Gene Id:494343
Rat Swiss Prot No:Q6P9Z6
Immunogen:The antiserum was produced against synthesized peptide derived from human TACD2. AA range:131-180
Specificity:TROP-2 Polyclonal Antibody detects endogenous levels of TROP-2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TACSTD2;GA733-1;M1S1;TROP2;Tumor-associated calcium signal transducer 2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1
Observed Band(KD):35kD
Background: This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009],
Function:disease:Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment.,function:GA733 tumor-associated antigen gene family may function as growth factor receptors.,PTM:The N-terminus is blocked.,similarity:Contains 1 thyroglobulin type-1 domain.,tissue specificity:Placenta, pancreatic carcinoma cell lines.,
Subcellular Location:Membrane; Single-pass type I membrane protein.
Expression:Placenta, pancreatic carcinoma cell lines.