Target：14-3-3 γ

Fields：Cell cycle;Oocyte meiosis;PI3K-Akt signaling pathway;Hippo signaling pathway;Hepatitis C;Viral carcinogenesis

Gene Name：YWHAG

Protein Name：14-3-3 protein gamma

Human Gene Id：7532

Human Swiss Prot No：P61981

Mouse Gene Id：22628

Mouse Swiss Prot No：P61982

Rat Gene Id：56010

Rat Swiss Prot No：P61983

Immunogen：The antiserum was produced against synthesized peptide derived from human 14-3-3 gamma. AA range:51-100

Specificity：14-3-3 γ Polyclonal Antibody detects endogenous levels of 14-3-3 γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：YWHAG;14-3-3 protein gamma;Protein kinase C inhibitor protein 1;KCIP-1

Observed Band(KD)：28kD

Background： This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008],

Function：function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:Phosphorylated by various PKC isozymes.,similarity:Belongs to the 14-3-3 family.,subunit:Homodimer. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.,tissue specificity:Highly expressed in brain, skeletal muscle, and heart.,

Subcellular Location：Cytoplasm .

Expression：Highly expressed in brain, skeletal muscle, and heart.