Target：TRIP15

Gene Name：COPS2

Protein Name：COP9 signalosome complex subunit 2

Human Gene Id：9318

Human Swiss Prot No：P61201

Mouse Gene Id：12848

Mouse Swiss Prot No：P61202

Rat Gene Id：261736

Rat Swiss Prot No：P61203

Immunogen：The antiserum was produced against synthesized peptide derived from human COPS2. AA range:181-230

Specificity：TRIP15 Polyclonal Antibody detects endogenous levels of TRIP15 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：COPS2;CSN2;TRIP15;COP9 signalosome complex subunit 2;SGN2;Signalosome subunit 2;Alien homolog;JAB1-containing signalosome subunit 2;Thyroid receptor-interacting protein 15;TR-interacting protein 15;TRIP-15

Observed Band(KD)：55kD

Background：function:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.,PTM:Phosphorylated by CK2 and PKD kinases.,similarity:Belongs to the CSN2 family.,similarity:Contains 1 PCI domain.,subunit:Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1.,

Function：function:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.,PTM:Phosphorylated by CK2 and PKD kinases.,similarity:Belongs to the CSN2 family.,similarity:Contains 1 PCI domain.,subunit:Interact

Subcellular Location：Cytoplasm . Nucleus .

Expression： Brain,Coronary artery,Pituitary,Skeletal muscle,