Target:Translin
Gene Name:TSN
Protein Name:Translin
Human Gene Id:7247
Human Swiss Prot No:Q15631
Mouse Gene Id:22099
Mouse Swiss Prot No:Q62348
Immunogen:The antiserum was produced against synthesized peptide derived from human TSN. AA range:101-150
Specificity:Translin Polyclonal Antibody detects endogenous levels of Translin protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TSN;Translin;Component 3 of promoter of RISC;C3PO
Observed Band(KD):26kD
Background: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012],
Function:function:DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots.,similarity:Belongs to the translin family.,subunit:Forms a multimeric ring-shaped structure. Interacts with TSNAX.,
Subcellular Location:Cytoplasm . Nucleus .
Expression: Liver,Lung,