Target:β-1,3-Gal-TL
Fields:Other types of O-glycan biosynthesis
Gene Name:B3GALTL
Protein Name:Beta-1,3-glucosyltransferase
Human Gene Id:145173
Human Swiss Prot No:Q6Y288
Mouse Swiss Prot No:Q8BHT6
Immunogen:The antiserum was produced against synthesized peptide derived from human B3GALTL. AA range:449-498
Specificity:β-1,3-Gal-TL Polyclonal Antibody detects endogenous levels of β-1,3-Gal-TL protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:B3GALTL;B3GTL;Beta-1;3-glucosyltransferase;Beta3Glc-T;Beta-3-glycosyltransferase-like
Observed Band(KD):57kD
Background: The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009],
Function:disease:Defects in B3GALTL are the cause of Peters-plus syndrome (PPS) [MIM:261540]. PPS is an autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate.,function:O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family.,tissue specificity:Widely expressed, with highest levels in testis and uterus.,
Subcellular Location:Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
Expression:Widely expressed, with highest levels in testis and uterus.