Target：FoxK1

Gene Name：FOXK1

Protein Name：Forkhead box protein K1

Human Gene Id：221937

Human Swiss Prot No：P85037

Mouse Gene Id：17425

Mouse Swiss Prot No：P42128

Immunogen：The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730

Specificity：FoxK1 Polyclonal Antibody detects endogenous levels of FoxK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FOXK1;MNF;Forkhead box protein K1;Myocyte nuclear factor;MNF

Observed Band(KD)：78kD

Background：function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.,PTM:Phosphorylated.,similarity:Contains 1 FHA domain.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with SIN3B to form a complex which represses transcription.,tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,

Function：function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.,PTM:Phosphorylated.,similarity:Contains 1 FHA domain.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with SIN3B to form a complex which represses transcription.,tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,

Subcellular Location：Nucleus . Cytoplasm . Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). .

Expression：Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879).