Target：5NTC

Fields：Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nucleotide metabolism

Gene Name：NT5C2 NT5B NT5CP PNT5

Protein Name：Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)

Human Gene Id：22978

Human Swiss Prot No：P49902

Mouse Swiss Prot No：Q3V1L4

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：5NTC Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：61kD

Background： This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011],

Function：catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Binds 1 magnesium ion per subunit.,disease:Aberration of this enzyme may be related to the urate production in hyperuricemia and gout.,enzyme regulation:Allosterically activated by various compounds, including ATP.,function:May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.,similarity:Belongs to the 5'(3')-deoxyribonucleotidase family.,subunit:Homotetramer.,

Subcellular Location：Cytoplasm, cytosol .

Expression：Widely expressed.