Target：AMPD2

Fields：Purine metabolism;Metabolic pathways;Nucleotide metabolism

Gene Name：AMPD2

Protein Name：AMP deaminase 2

Human Gene Id：271

Human Swiss Prot No：Q01433

Mouse Gene Id：109674

Mouse Swiss Prot No：Q9DBT5

Rat Gene Id：362015

Rat Swiss Prot No：Q02356

Immunogen：The antiserum was produced against synthesized peptide derived from human AMPD2. AA range:131-180

Specificity：AMPD2 Polyclonal Antibody detects endogenous levels of AMPD2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AMPD2;AMP deaminase 2;AMP deaminase isoform L

Observed Band(KD)：100kD

Background： The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

Function：catalytic activity:AMP + H(2)O = IMP + NH(3).,function:AMP deaminase plays a critical role in energy metabolism.,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.,similarity:Belongs to the adenosine and AMP deaminases family.,subunit:Homotetramer.,tissue specificity:Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.,

Subcellular Location：cytosol,

Expression：Highly expressed in cerebellum.