Target：TADA2L

Gene Name：TADA2A

Protein Name：Transcriptional adapter 2-alpha

Human Gene Id：6871

Human Swiss Prot No：O75478

Mouse Gene Id：217031

Mouse Swiss Prot No：Q8CHV6

Rat Gene Id：360581

Rat Swiss Prot No：Q6AYE3

Immunogen：The antiserum was produced against synthesized peptide derived from human ADA2L. AA range:206-255

Specificity：TADA2L Polyclonal Antibody detects endogenous levels of TADA2L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TADA2A;TADA2L;KL04P;Transcriptional adapter 2-alpha;Transcriptional adapter 2-like;ADA2-like protein

Observed Band(KD)：47kD

Background： Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009],

Function：function:Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP.,tissue specificity:Expressed in all tissues, but most abundantly in testis.,

Subcellular Location：Nucleus . Chromosome .

Expression：Expressed in all tissues, but most abundantly in testis.