Target：IL-20

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;JAK-STAT signaling pathway

Gene Name：IL20

Protein Name：Interleukin-20

Human Gene Id：50604

Human Swiss Prot No：Q9NYY1

Mouse Gene Id：58181

Mouse Swiss Prot No：Q9JKV9

Immunogen：The antiserum was produced against synthesized peptide derived from human IL-20. AA range:12-61

Specificity：IL-20 Polyclonal Antibody detects endogenous levels of IL-20 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL20;ZCYTO10;Interleukin-20;IL-20;Cytokine Zcyto10

Observed Band(KD)：28kD

Background： The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008],

Function：function:Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.,similarity:Belongs to the IL-10 family.,tissue specificity:Expressed at very low levels in skin, trachea, and other tissues.,

Subcellular Location：Secreted.

Expression：Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.