Target：IL-1RII

Fields：Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Amoebiasis;Human T-cell leukemia virus 1 infection;Transcriptional misregulation in cancer;Prostate cancer;Fluid shear stress and atherosclerosis

Gene Name：IL1R2

Protein Name：Interleukin-1 receptor type 2

Human Gene Id：7850

Human Swiss Prot No：P27930

Mouse Swiss Prot No：P27931

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2. AA range:141-190

Specificity：IL-1RII Polyclonal Antibody detects endogenous levels of IL-1RII protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL1R2;IL1RB;Interleukin-1 receptor type 2;IL-1R-2;IL-1RT-2;IL-1RT2;CD121 antigen-like family member B;CDw121b;IL-1 type II receptor;Interleukin-1 receptor beta;IL-1R-beta;Interleukin-1 receptor type II;CD121b

Observed Band(KD)：43kD

Background： The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012],

Function：function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,

Subcellular Location：[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane; Single-pass type I membrane protein.

Expression： B-cell,Colon,Ovary,