Target：IL-19

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;JAK-STAT signaling pathway

Gene Name：IL19 ZMDA1

Protein Name：Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)

Human Gene Id：29949

Human Swiss Prot No：Q9UHD0

Mouse Gene Id：329244

Mouse Swiss Prot No：Q8CJ70

Immunogen：Synthetic peptide from human protein at AA range: 51-100

Specificity：The antibody detects endogenous IL-19

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Interleukin-19 (IL-19;Melanoma differentiation-associated protein-like protein;NG.1)

Observed Band(KD)：20kD

Background： The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008],

Function：function:May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.,similarity:Belongs to the IL-10 family.,

Subcellular Location：Secreted.