Target：Ameloblastin

Gene Name：AMBN

Protein Name：Ameloblastin

Human Gene Id：258

Human Swiss Prot No：Q9NP70

Mouse Swiss Prot No：O55189

Immunogen：The antiserum was produced against synthesized peptide derived from human Ameloblastin. AA range:275-324

Specificity：Ameloblastin Polyclonal Antibody detects endogenous levels of Ameloblastin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AMBN;Ameloblastin

Observed Band(KD)：48kD

Background： This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011],

Function：disease:Defects in AMBN are found in patients with ameloblastomas.,function:Involved in the mineralization and structural organization of enamel.,similarity:Belongs to the ameloblastin family.,tissue specificity:Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.,

Subcellular Location：Secreted, extracellular space, extracellular matrix.

Expression：Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.