Target：IL-17F

Fields：Cytokine-cytokine receptor interaction;IL-17 signaling pathway;Th17 cell differentiation;Inflammatory bowel disease

Gene Name：IL17F IL24

Protein Name：Interleukin-17F (IL-17F) (Cytokine ML-1) (Interleukin-24) (IL-24)

Human Gene Id：112744

Human Swiss Prot No：Q96PD4

Mouse Gene Id：257630

Mouse Swiss Prot No：Q7TNI7

Immunogen：Synthetic peptide from human protein at AA range: 81-130

Specificity：The antibody detects endogenous IL-17F

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Interleukin-17F (IL-17F;Cytokine ML-1;Interleukin-24;IL-24)

Background： The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008],

Function：function:Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.,online information:Interleukin-17 entry,similarity:Belongs to the IL-17 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.,

Subcellular Location：Secreted .

Expression：Expressed in T-helper 1 and T-helper 2 cells, basophils and mast cells.