Target：IL-13Rα2

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway

Gene Name：IL13RA2

Protein Name：Interleukin-13 receptor subunit alpha-2

Human Gene Id：3598

Human Swiss Prot No：Q14627

Mouse Swiss Prot No：O88786

Immunogen：Synthesized peptide derived from Interleukin-13 receptor subunit alpha-2 at AA range: 241-290

Specificity：IL-13Rα2 Polyclonal Antibody detects endogenous levels of IL-13Rα2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL13RA2;IL13R;Interleukin-13 receptor subunit alpha-2;IL-13 receptor subunit alpha-2;IL-13R subunit alpha-2;IL-13R-alpha-2;IL-13RA2;Interleukin-13-binding protein;CD213a2

Observed Band(KD)：44kD

Background： The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008],

Function：domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds as a monomer with high affinity to interleukin 13 (IL13), but not to IL4.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,similarity:Contains 1 fibronectin type-III domain.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression： Brain,Lung,Prostate,Renal cell carcinoma,Testis,