Target：T2R5

Fields：Taste transduction

Gene Name：TAS2R5

Protein Name：Taste receptor type 2 member 5

Human Gene Id：54429

Human Swiss Prot No：Q9NYW4

Immunogen：The antiserum was produced against synthesized peptide derived from human TAS2R5. AA range:178-227

Specificity：T2R5 Polyclonal Antibody detects endogenous levels of T2R5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAS2R5;Taste receptor type 2 member 5;T2R5

Observed Band(KD)：35kD

Background： This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],

Function：function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression：Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.