Target：IKBL1

Gene Name：NFKBIL1 IKBL

Protein Name：NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)

Human Gene Id：4795

Human Swiss Prot No：Q9UBC1

Mouse Swiss Prot No：O88995

Rat Swiss Prot No：Q8R2H1

Immunogen：Synthesized peptide derived from human protein . at AA range: 70-150

Specificity：IKBL1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：41kD

Background： This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009],

Function：disease:Mutations in the promoter region of NFKBIL1 represent the second rheumatoid arthritis susceptibility locus within the HLA region [MIM:180300].,function:May be a negative regulator of NF-kappa-B activation.,similarity:Contains 2 ANK repeats.,tissue specificity:Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.,

Subcellular Location：Nucleus . Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.

Expression：Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.