Target：Ikaros 3

Gene Name：IKZF3

Protein Name：Zinc finger protein Aiolos

Human Gene Id：22806

Human Swiss Prot No：Q9UKT9

Mouse Gene Id：22780

Mouse Swiss Prot No：O08900

Immunogen：The antiserum was produced against synthesized peptide derived from human IKZF3. AA range:361-410

Specificity：Ikaros 3 Polyclonal Antibody detects endogenous levels of Ikaros 3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IKZF3;ZNFN1A3;Zinc finger protein Aiolos;Ikaros family zinc finger protein 3

Observed Band(KD)：62kD

Background： This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012],

Function：function:Transcription factor that plays an important role in the regulation of lymphocyte differentiation.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.,

Subcellular Location：Nucleus . Cytoplasm .; [Isoform 1]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 11]: Nucleus .; [Isoform 14]: Nucleus . Cytoplasm .; [Isoform 12]: Cytoplasm .

Expression：Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.