Target：IK
Gene Name：IK
Protein Name：Protein Red
Human Gene Id：3550
Human Swiss Prot No：Q13123
Mouse Gene Id：24010
Mouse Swiss Prot No：Q9Z1M8
Rat Gene Id：291659
Rat Swiss Prot No：Q66HG8
Immunogen：The antiserum was produced against synthesized peptide derived from human RED. AA range:508-557
Specificity：IK Polyclonal Antibody detects endogenous levels of IK protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IK;RED;RER;Protein Red;Cytokine IK;IK factor;Protein RER
Observed Band(KD)：66kD
Background： The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008],
Function：caution:Was originally (PubMed:7970704) thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.,developmental stage:Expressed at similar levels in fetal and adult tissues.,function:Not known. May bind to chromatin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RED family.,tissue specificity:Ubiquitous.,
Subcellular Location：Nucleus . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, spindle pole . Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768). .
Expression：Ubiquitous.
