Target:Synuclein-β
Gene Name:SNCB
Protein Name:Beta-synuclein
Human Gene Id:6620
Human Swiss Prot No:Q16143
Mouse Gene Id:104069
Mouse Swiss Prot No:Q91ZZ3
Rat Gene Id:113893
Rat Swiss Prot No:Q63754
Immunogen:The antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134
Specificity:Synuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SNCB;Beta-synuclein
Observed Band(KD):14kD
Background: This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Function:disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs
Subcellular Location:Cytoplasm.
Expression:Expressed predominantly in brain; concentrated in presynaptic nerve terminals.