Target：I-FABP

Fields：PPAR signaling pathway;Fat digestion and absorption

Gene Name：FABP2 FABPI

Protein Name：Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)

Human Gene Id：2169

Human Swiss Prot No：P12104

Mouse Gene Id：14079

Mouse Swiss Prot No：P55050

Rat Swiss Prot No：P02693

Immunogen：Synthetic peptide from human protein at AA range: 90-132

Specificity：The antibody detects endogenous I-FABP

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2;Intestinal-type fatty acid-binding protein;I-FABP)

Observed Band(KD)：15kD

Background： The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008],

Function：domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,function:FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.,induction:By EGF.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.,

Subcellular Location：Cytoplasm.

Expression：Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.