Target：SV2A

Fields：ECM-receptor interaction

Gene Name：SV2A KIAA0736 PSEC0174

Protein Name：Synaptic vesicle glycoprotein 2A

Human Gene Id：9900

Human Swiss Prot No：Q7L0J3

Mouse Swiss Prot No：Q9JIS5

Rat Swiss Prot No：Q02563

Immunogen：Synthesized peptide derived from part region of human protein. AA range 30-80

Specificity：SV2A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：81kD

Background： The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016],

Function：function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.,miscellaneous:Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.,PTM:N-glycosylated.,PTM:Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.,subunit:Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.,

Subcellular Location：Cell junction, synapse, presynapse . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. .

Expression： Brain,Brain cortex,Ovary,Retina,Teratocarcinoma,