Target:ID3
Fields:TGF-beta signaling pathway;Signaling pathways regulating pluripotency of stem cells
Gene Name:ID3 1R21 BHLHB25 HEIR1
Protein Name:DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3)
Human Gene Id:3399
Human Swiss Prot No:Q02535
Mouse Swiss Prot No:P41133
Rat Swiss Prot No:P41138
Immunogen:Synthesized peptide derived from human protein . at AA range: 68-117
Specificity:ID3 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):13kD
Background: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011],
Function:function:ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.,induction:By phorbol 12-myristate 13-acetate (PMA).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with COPS5 and COPS7A (By similarity). Homodimer, and heterodimer with other HLH proteins.,tissue specificity:Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.,
Subcellular Location:Nucleus.
Expression:Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.