Target:ICAM-2
Fields:Cell adhesion molecules;Natural killer cell mediated cytotoxicity
Gene Name:ICAM2
Protein Name:Intercellular adhesion molecule 2
Human Gene Id:3384
Human Swiss Prot No:P13598
Mouse Swiss Prot No:P35330
Immunogen:The antiserum was produced against synthesized peptide derived from human ICAM2. AA range:151-200
Specificity:ICAM-2 Polyclonal Antibody detects endogenous levels of ICAM-2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:ICAM2;Intercellular adhesion molecule 2;ICAM-2;CD antigen CD102
Observed Band(KD):30kD
Background: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Function:function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.,online information:ICAM-2,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,
Subcellular Location:Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Co-localizes with RDX, EZR and MSN in microvilli. .
Expression: Aorta endothelial cell,Blood,Brain,Endothelial cell,Plasma,Spleen,