Target：SUH

Fields：Notch signaling pathway;Th1 and Th2 cell differentiation;Spinocerebellar ataxia;Human papillomavirus infection;Epstein-Barr virus infection;Viral carcinogenesis

Gene Name：RBPJ IGKJRB IGKJRB1 RBPJK RBPSUH

Protein Name：Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)

Human Gene Id：3516

Human Swiss Prot No：Q06330

Mouse Swiss Prot No：P31266

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SUH Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background： The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013],

Function：caution:Despite some similarity with the "phage" integrase family, it has no recombinase activity.,function:Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.,similarity:Belongs to the Su(H) family.,similarity:Contains 1 IPT/TIG domain.,subunit:Interacts with activated NOTCH1,

Subcellular Location：Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.

Expression： Eye,Placenta,Renal cell carcinoma,T