Target：AQP5

Fields：Salivary secretion

Gene Name：AQP5

Protein Name：Aquaporin-5

Human Gene Id：362

Human Swiss Prot No：P55064

Mouse Swiss Prot No：Q9WTY4

Immunogen：The antiserum was produced against synthesized peptide derived from human AQP5. AA range:194-243

Specificity：AQP5 Polyclonal Antibody detects endogenous levels of AQP5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AQP5;Aquaporin-5;AQP-5

Observed Band(KD)：35kD

Background： Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008],

Function：domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,

Subcellular Location：Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. .

Expression：Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level).