Target：Stonin-1

Gene Name：STON1

Protein Name：Stonin-1

Human Gene Id：11037

Human Swiss Prot No：Q9Y6Q2

Mouse Swiss Prot No：Q8CDJ8

Immunogen：The antiserum was produced against synthesized peptide derived from human STON1. AA range:686-735

Specificity：Stonin-1 Polyclonal Antibody detects endogenous levels of Stonin-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：STON1;SALF;SBLF;STN1;Stonin-1;Stoned B-like factor

Observed Band(KD)：83kD

Background：stonin 1(STON1) Homo sapiens Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:May be involved in the endocytic machinery.,function:May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.,miscellaneous:In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1.,sequence caution:Chimeric cDNA. The biological existence and relevance of this product of both SALF (AC Q9Y6Q2) and GTF2A1LF genes, creating a chimeric protein of 1182 residues is uncertain.,sequence caution:Chimeric cDNA. The biological existence and relevance of this product of both SALF and GTF2A1LF (AC Q9UNN4) genes, which codes for a chimeric protein of 1

Subcellular Location：Cytoplasm . Membrane . Some fraction is membrane-associated.

Expression：Ubiquitous.