Target：STEAP2

Fields：Mineral absorption

Gene Name：STEAP2

Protein Name：Metalloreductase STEAP2

Human Gene Id：261729

Human Swiss Prot No：Q8NFT2

Mouse Gene Id：74051

Mouse Swiss Prot No：Q8BWB6

Immunogen：The antiserum was produced against synthesized peptide derived from human STEA2. AA range:431-480

Specificity：STEAP2 Polyclonal Antibody detects endogenous levels of STEAP2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：STEAP2;PCANAP1;STAMP1;Metalloreductase STEAP2;Prostate cancer-associated protein 1;Protein up-regulated in metastatic prostate cancer;PUMPCn;Six-transmembrane epithelial antigen of prostate 2;SixTransMembrane protein of prostate 1

Molecular Weight(Da)：56kD

Background：STEAP2 metalloreductase(STEAP2) Homo sapiens This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Function：cofactor:FAD.,function:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,tissue specificity:Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.,

Subcellular Location：Endosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

Expression：Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.