Target:StARD13
Gene Name:STARD13
Protein Name:StAR-related lipid transfer protein 13
Human Gene Id:90627
Human Swiss Prot No:Q9Y3M8
Mouse Gene Id:243362
Mouse Swiss Prot No:Q923Q2
Immunogen:The antiserum was produced against synthesized peptide derived from human STA13. AA range:101-150
Specificity:StARD13 Polyclonal Antibody detects endogenous levels of StARD13 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:STARD13;DLC2;GT650;StAR-related lipid transfer protein 13;46H23.2;Deleted in liver cancer 2 protein;DLC-2;Rho GTPase-activating protein;START domain-containing protein 13;StARD13
Observed Band(KD):125kD
Background: This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
Function:function:GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,subunit:Homodimer. Interacts with TAX1BP1.,tissue specificity:Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.,
Subcellular Location:Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Expression:Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.