Target：STAM1

Fields：Endocytosis;JAK-STAT signaling pathway

Gene Name：STAM STAM1

Protein Name：Signal transducing adapter molecule 1 (STAM-1)

Human Gene Id：8027

Human Swiss Prot No：Q92783

Mouse Swiss Prot No：P70297

Immunogen：Synthesized peptide derived from part region of human protein AA range: 156-206

Specificity：STAM1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：59kD

Background： This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011],

Function：function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.,PTM:Phosphorylated on Tyr-198. Phosphorylation occurs in response to IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF.,similarity:Belongs to the STAM family.,similarity:Contains 1 ITAM domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,similarity:Contains 1 VHS domain.,subunit:Com

Subcellular Location：Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .

Expression：Ubiquitously expressed.