Target：ST2

Fields：Cytokine-cytokine receptor interaction

Gene Name：IL1RL1 DER4 ST2 T1

Protein Name：Interleukin-1 receptor-like 1 (Protein ST2)

Human Gene Id：9173

Human Swiss Prot No：Q01638

Mouse Gene Id：17082

Mouse Swiss Prot No：P14719

Immunogen：Synthetic peptide from human protein at AA range: 251-300

Specificity：The antibody detects endogenous ST2

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Interleukin-1 receptor-like 1 (Protein ST2)

Molecular Weight(Da)：63kD

Background： The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Function：function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,

Subcellular Location：[Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .

Expression：Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.