Target:SSTR4
Fields:Neuroactive ligand-receptor interaction
Gene Name:SSTR4
Protein Name:Somatostatin receptor type 4
Human Gene Id:6754
Human Swiss Prot No:P31391
Mouse Swiss Prot No:P49660
Rat Gene Id:25555
Rat Swiss Prot No:P30937
Immunogen:The antiserum was produced against synthesized peptide derived from human SSTR4. AA range:155-204
Specificity:SSTR4 Polyclonal Antibody detects endogenous levels of SSTR4 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SSTR4;Somatostatin receptor type 4;SS-4-R;SS4-R;SS4R
Observed Band(KD):42kD
Background: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008],
Function:function:Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.