Target:SSH3
Fields:Axon guidance;Regulation of actin cytoskeleton
Gene Name:SSH3
Protein Name:Protein phosphatase Slingshot homolog 3
Human Gene Id:54961
Human Swiss Prot No:Q8TE77
Mouse Gene Id:245857
Mouse Swiss Prot No:Q8K330
Rat Gene Id:365396
Rat Swiss Prot No:Q5XIS1
Immunogen:The antiserum was produced against synthesized peptide derived from human SSH3. AA range:357-406
Specificity:SSH3 Polyclonal Antibody detects endogenous levels of SSH3 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SSH3;SSH3L;Protein phosphatase Slingshot homolog 3;SSH-like protein 3;SSH-3L;hSSH-3L
Observed Band(KD):74kD
Background: The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
Function:catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,
Subcellular Location:Cytoplasm, cytoskeleton . Nucleus .
Expression: Cerebellum,Epithelium,Ovarian carcinoma,Uterus,