Target:SSBP1
Fields:DNA replication;Mismatch repair;Homologous recombination
Gene Name:SSBP1
Protein Name:Single-stranded DNA-binding protein mitochondrial
Human Gene Id:6742
Human Swiss Prot No:Q04837
Mouse Gene Id:381760
Mouse Swiss Prot No:Q9CYR0
Rat Gene Id:54304
Rat Swiss Prot No:P28042
Immunogen:The antiserum was produced against synthesized peptide derived from human MtSSB. AA range:99-148
Specificity:SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SSBP1;SSBP;Single-stranded DNA-binding protein; mitochondrial;Mt-SSB;MtSSB;PWP1-interacting protein 17
Observed Band(KD):17kD
Background: SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010],
Function:function:This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SSB domain.,subunit:Homotetramer.,
Subcellular Location:Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
Expression:Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).