Target：A Cyclase VII

Fields：Purine metabolism;Metabolic pathways;Endocrine resistance;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;Oocyte meiosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Apelin signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion;Relaxin signaling pathway;Cort

Gene Name：ADCY7

Protein Name：Adenylate cyclase type 7

Human Gene Id：113

Human Swiss Prot No：P51828

Mouse Gene Id：11513

Mouse Swiss Prot No：P51829

Immunogen：The antiserum was produced against synthesized peptide derived from human ADCY7. AA range:191-240

Specificity：A Cyclase VII Polyclonal Antibody detects endogenous levels of A Cyclase VII protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADCY7;KIAA0037;Adenylate cyclase type 7;ATP pyrophosphate-lyase 7;Adenylate cyclase type VII;Adenylyl cyclase 7

Molecular Weight(Da)：120kD

Background： This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013],

Function：catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression： Blood,Bone marrow,